in my first look through the 2.22 i noticed so many little differences that could bo so important, that i might dig them up tommorow, but one thing stroke me like a thunder:
After Unit-02 Backflip thing, does the original scene after that really looking crappy, or is it just my and my rip?
Nevertheless im pretty happy, most changes buffed up the clarity and gave us more Details to enjoy ( like different face of Shinji while pulling zeruels arm right before power goes off, or completely different sound after kaoru interrupts the 3I sequence..).
But i dig that up later, there really many things to be found.

EDIT:
Okay i list somethings up before i forget them , a rewatch with notebook will cost time so here it comes. (NOt in Order)
-Sahaquiel in his first form is darker , more shadows, more Blurr-effect on the edge
- Sahaqiels small err arms? are black now
- I think the addet that blurr effekt in the ZABEASTO mode in the Entry plug
While activating Za beasto, you can notice how those regulators of the plugsuit are moving on the (left) shoulder (like its making the plug suit tighter?) and no i dont talk about the green glowing things. dont know if it was too in 2.0, but i noticed that in 2.22 first.
- That Zoom on maris Eye while eating the layers of zeruels AT field , and that thing many people thought was her eye blinking sideways or some sort of that, is actually her Glassbreaking ( so no super Allien theorys to advance her , see what i did there?!11)
-While Shinji is sitting in the Death train after Bardiel- Fight you can notice how he has his earplugs first in his ears, only too see that a few seconds after that his player is above him and now anymore attached to him + im sure they added generally somthing in that scene that i cant pull of right now( of course that thing is a stylistic device by anno, Shin seiki should please analyze this in his surely coming PHD work about Rebuild of EVA)
-While bardiel is infeting unit 1, you can see that in that places which change to blue colour, there are growing some kind of Metal Ladder, and not in Order, just randomizes growing ( any meaning behind that?)
- Did those second pair of Bardiel arms look like Asuka`s arms WITH plugsuit at the shoulder part? ( i know they looked human and probably like asukas in 2.0 before)
- They added lots of Sparks and stuff like that ( e.g. unit one running to sahaquiel on the route chaning system, Zeruel blowing the upper geofront with his shot , many electricity sparcs)
- Adding of more glowing edges at the space shot of unit 4(?) exploding
+ Same kind of Edge glowing at the Impact start sequence at the end on the halo of Unit 01
- While seeing Unit -03 beeing lifted up to hiss (her ;P) transoport to Japan you can see that it is going too fly through Clouds which are stormy an many thunders are happening (like in the series , the Omen of something bad too happen or actually the place where the contamination happens?)
- Zeruel after merging with Unit 00 is glowing like a rainbow in the transistion phase of the Body
Well that should be it, after looking through it once more i may find even more stuff ( or maybe BD will have some little differences to DVD too?)
Over and out
( sorry for grammar, writing this post very late and very nervous due too beeing hyperhigh after watching RoE 2.22 )