I don't know anyone who assumes that directly, seeing as how the shadows clearly belong to people and are accompanied by a statement about the "fated meeting of the Children". Now, one could easily assume that there's some connection between the four Children in question and the four Second Impact Adams, but that's something else entirely.
As for my entries:
-The four pilots are the carriers of the Adams' souls.
-Terminal Dogma crucified marshmallow is...still Lilith. (Mostly because we have no notion of a unified Adam entity so far).
-Lilith was somehow involved in Second Impact, and so was Misato. Kaworu is Lilith's soul in a body derived from Misato somehow, don't ask me how.
-Gendou's plan is no longer to try and bring Yui back; instead, he's simply doing as she instructed him to do. (Unless he already said what his plan was in Rebuild, I can't remember). Therefore, while she puts herself in position to become a godlike being, he is her "eyes on the outside," manipulating things in her favor.
-Kaji kills someone very important at NERV (leaning towards Misato).
-In the last scene, the oceans will go back to being blue. However, the ending will still be sad.
-Gendou dies protecting Shinji. Alternatively, Shinji winds up having to kill Gendou.
-There will be at least one more repetition of the fucking "oh no there is a penguin in this bathroom i guess i had better go expose myself because i am PANICKING, what high comedy this is" scene. Not sure if it's Kaworu or Mari, but it's going to happen.
-There will be rebodied/human Yui at some point.
-Shinji dies, and stays dead.
-Giant Naked Rei shows up again, just like she was in EoE, and dies. Jury's still out on regular Rei.
-There will be a final boss. It will be stupid.
-There will be a "ten years later" epilogue. It will be stupid.
-They will use that terrible, terrible remix of Zankoku na Tenshi no These at some point. It will be beyond stupid.
-Unit 07 already exists and we've seen it before, and it's not a conventional Eva.
-Unit 08 is Lilith (post-liposuction), not Unit 01.