Posting this because this caught my eye (bold is from me)...
[W]hen I am working on Evangelion, Hideaki Anno will ask me to change the design a little or change the colors choices. Anno is looking for something very different from the norm while Hosoda won't ask for changes. Hosoda may be looking for something more mainstream, like Studio Ghibli's work. He may not be looking for otaku appeal in the designs. Anno will pull inspiration from animation from his childhood and may want to show something more exciting and infuse his childhood passions into his projects. Those are the big differences between each director's work.